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Sensitisation waves in a bidomain fire-diffuse-fire model of intracellular Ca²⁺ dynamics

机译:细胞内Ca 2+动力学的双域火扩散火模型中的敏化波

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摘要

We present a bidomain threshold model of intracellular calcium (Ca²⁺) dynamics in which, as suggested by recent experiments, the cytosolic threshold for Ca²⁺ liberation is modulated by the Ca²⁺ concentration in the releasing compartment. We explicitly construct stationary fronts and determine their stability using an Evans function approach. Our results show that a biologically motivated choice of a dynamic threshold, as opposed to a constant threshold, can pin stationary fronts that would otherwise be unstable. This illustrates a novel mechanism to stabilise pinned interfaces in continuous excitable systems. Our framework also allows us to compute travelling pulse solutions in closed form and systematically probe the wave speed as a function of physiologically important parameters. We find that the existence of travelling wave solutions depends on the time scale of the threshold dynamics, and that facilitating release by lowering the cytosolic threshold increases the wave speed. The construction of the Evans function for a travelling pulse shows that of the co-existing fast and slow solutions the slow one is always unstable.
机译:我们提供了一种细胞内钙(Ca 2+)动力学的双域阈值模型,其中,正如最近的实验所表明的,Ca 2+释放的胞质阈值受释放区室中Ca 2+浓度的调节。我们显式构造固定前沿,并使用Evans函数方法确定其稳定性。我们的结果表明,动态阈值的生物学选择(而不是恒定阈值)可以固定固定的前沿,否则这些前沿将变得不稳定。这说明了一种稳定连续激励系统中固定接口的新颖机制。我们的框架还允许我们以封闭形式计算行进脉冲解,并系统地根据生理重要参数来探测波速。我们发现行波解的存在取决于阈值动力学的时间尺度,并且通过降低胞质阈值促进释放加快了波速。 Evans函数对于行进脉冲的构造表明,在快速和慢速共存的解决方案中,慢速始终是不稳定的。

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